Introduction: In September 2022, an outbreak of an unknown disease was reported in Mnamba village, Kalambo District, Rukwa Region. The disease presented with symptoms such as fever, headache, abdominal pain, cough, fatigue, diarrhea, and vomiting, with some cases involving blood in the vomit. 🤒 The Ministry of Health, in collaboration with TFELTP, responded promptly by deploying a rapid response team to investigate and contain the outbreak. 🚑Investigation Details: The team’s objectives included determining the outbreak’s magnitude, describing it in terms of time, place, and person, conducting contact tracing, and assessing environmental factors like clean water availability and sanitation. 💧 The team reviewed health records, updated linelists, and collected various samples from both patients and the environment, including blood, urine, stool, and food items. 🧪Outcome: The investigation found that most cases were adult males with a history of local alcohol consumption 🍶. The team’s swift and thorough response helped in identifying the outbreak’s source and mitigating its impact. Findings from this investigation will guide future outbreak responses, underlining the importance of continuous training and preparedness in public health. 🛡️